ReliSorb™ Industrial Protein Purification Resins

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Maintaining economical feasability is an increasing challenge when chromatographic protein purification processes have to be translated into larger industrial scale purifications. For high added value proteins, small particle size resins can be applied only up to a certain volume before technical limitations (pressure drop/limited bed height) and economical criteria limit the process. For lower added value proteins, like for instance often found in food and dairy markets the economical aspects are even more challenging. For these types of situations Mitsubishi/Resindion proposes the ReliSorb™ 400 and ReliSorb™ 405/EB series of protein chromatography media.

The ReliSorb™ 400 and ReliSorb™ 405/EB chromatography resins are resins based on highly hydrophilic macroporous methacrylates.

Bead SizesType 400/SS: 90 µm
Type 400: 120 µm
Type 405/EB: 300 µm (mean diameter)
Packs Sizes250 ml, 500 ml, 1 liter, 5 liter, 10 liter, 25 liter and drums
Ion ExchangeSP, CM, QA, DEAE
Hydrophobic InteractionPhenyl, butyl, octyl, octadecyl
Metal Chelator (IMAC)Iminodiacetic acid
Activated SupportsEpoxy, hydroxyl, short and long spacer arm primary amino groups

Ion exchange resins

Bead Size 50 – 150 µmBead Size 75 – 200 µmBead Size 200 – 500 µmStorage Solution At Delivery
ReliSorb™ CM400/SSReliSorb™ CM400ReliSorb™ CM405/EBEtOH 20% aqueous solutions + NaCl (final concentration 150 mM)
ReliSorb™ SP400/SSReliSorb™ SP400ReliSorb™ SP405/EBEtOH 20% aqueous solutions + NaCl (final concentration 150 mM)
ReliSorb™ DA400/SSReliSorb™ DA400ReliSorb™ DA405/EBEtOH 20% aqueous solutions + NaCl (final concentration 150 mM)
ReliSorb™ QA400/SSReliSorb™ QA400ReliSorb™ QA405/EBEtOH 20% aqueous solutions + NaCl (final concentration 150 mM)

Hydrophobic interactions resins

Bead Size 50 – 150 µmBead Size 75 – 200 µmBead Size 200 – 500 µmStorage Solution At Delivery
ReliSorb™ PH400/SSReliSorb™ PH400ReliSorb™ PH405/EBEtOH 20% aqueous solutions
ReliSorb™ BU400/SSReliSorb™ BU400ReliSorb™ BU405/EBEtOH 20% aqueous solutions
ReliSorb™ OD400/SSReliSorb™ OD400ReliSorb™ OD405/EBEtOH 20% aqueous solutions

Affinity resins

Bead Size 50 – 150 µmBead Size 75 – 200 µmBead Size 200 – 500 µmStorage Solution At Delivery
ReliSorb™ HG400/SSReliSorb™ HG400ReliSorb™ HG405/EBEtOH 20% aqueous solutions
ReliSorb™ IDA400/SSReliSorb™ IDA400ReliSorb™ IDA405/EBEtOH 20% aqueous solutions + NaCl (final concentration 150 mM)
ReliSorb™ EP400/SSReliSorb™ EP400ReliSorb™ EP405/EBWet form
ReliSorb™ SA400/SSReliSorb™ SA400ReliSorb™ SA405/EBEtOH 20% aqueous solutions + NaCl (final concentration 150 mM)
ReliSorb™ LA400/SSReliSorb™ LA400ReliSorb™ LA405/EBEtOH 20% aqueous solutions + NaCl (final concentration 150 mM)

Shown in the graph the Mitsubishi ReliSorb™ pressure drop in water at 25 ºC.

Further explanation:
Pressure drop per meter of bed depth in function of the linear velocity for the different types of available ReliSorb™.
The slope of the curves increases as the particle size range becomes smaller.

Mitsubishi ReliSorb™ pressure drop in water at 25 ºC
Column Dimensions8 mm ID x 100 mm
Sample LoadingAcid bovine serum in phosphate buffer 20 mM, pH 6.5
Buffer ElutionStep gradient with NaCl 0.25 – 0.5 – 1.0 M
Temperature25 ºC
Mitsubishi ReliSorb™ SP400/SS Lactoferrin purification example
Mitsubishi ReliChrom™ SP400/SS Lactoferrin purification example

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ReliSorb™ Industrial Protein Purification Resins

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