Sepabeads™ EC & ReliZyme™ Enzyme Immobilization Resins

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The use of enzymes represents a well-known and consolidated advantage compared to the conventional chemical processes, as demonstrated by some meaningful green industrial applications in both pharma and food areas. But often, denaturing caused by the operational conditions like solvent effect and mechanical shear forces prohibits recovery of enzymes from reaction solutions. Furthermore, separation of enzymes from substrates and products are in general difficult. Considering these aspects, enzyme immobilization represents a solution that allows overcoming such difficulties.

The general advantages of immobilizing enzymes to a solid support:

  • Multiple or repetitive use of a single batch of immobilised enzymes
  • Ability to rapidly stop the reaction by removing the immobilized enzyme from the reaction solution (or vice versa)
  • Immobilization allows the use of higher enzyme concentrations in the reaction environment
  • Possibility to apply continuous processes in CSTR reactors as well as fixed or expanded bed column reactors
  • Increased operational stability

For further general information, download the ReliZyme™ & Sepabeads™ EC Brochure and Technical Sheet below.

Product NameFunctionalityActivationBindingEnzyme Reactive Groups
ReliZyme™ EP
Sepabeads™ EC-EP
Epoxy
Epoxy
Covalent (high molarity)-SH -NHR -NH2 -OH
ReliZyme™ HFA
Sepabeads™ EC-HFA
Amino Epoxy
Amino-Epoxy
Covalent (low molarity)-SH -NHR -NH2 -OH
ReliZyme™ HG
Sepabeads™ EC-HG
1,2 Diol
1,2 Diol
NalO4 (CNBr)Covalent (low molarity)Primary amines -NH2
ReliZyme™ EA
Sepabeads™ EC-EA
Ethylamino
Ethylamino
GlutardialdehydeCovalent (low molarity)Primary amines -NH2
ReliZyme™ HA
Sepabeads™ EC-HA
Hexamethylamino
Hexamethylamino
GlutardialdehydeCovalent (low molarity)Primary amines -NH2
ReliZyme™ QA
Sepabeads™ EC-QA
Quaternary Ammonium
Quaternary Ammonium
Ionic adsorption (low molarity)Negatively charged
ReliZyme™ BU
Sepabeads™ EC-BU
Butyl
Butyl
Physical adsorptionHydrophobic lid
ReliZyme™ OC
Sepabeads™ EC-OC
Octyl
Octyl
Physical adsorptionHydrophobic lid
ReliZyme™ OD
Sepabeads™ EC-OD
Octadecyl
Octadecyl
Physical adsorptionHydrophobic lid

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Sepabeads™ EC & ReliZyme™ Enzyme Immobilization Resins

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